Picking up on a suggestion from leeiii, here's a continuing post on which you're all welcome to list Shelbyville streets (or county roads, for that matter) and what could formerly be found along them and when.
Depot Street in the 1970s: A Rexall drug store was in the corner building now occupied by Jo Jo's (and that building was First National Bank in the 1920s -- it's engraved near the roof). Also on that block were Peoples National Bank, Castner-Knott and H & H Department Store. Across the street, in the building which collapsed last year, was, I think, Hames-Daughtery Drug Store in the 1960s. Down the street were Shelbyville Sport Shop (not Sport's'), Shelbyville Record Shop when Austin Davis still sold records, and across the street were the Princess/Capri Theater and the furniture store known as Lewis & Thomas, Woosley & Thomas and several other names over the years. Cannon Chevrolet was in the big empty lot across from First Baptist Church (seems like a good place for a convenience store today) and a used car dealership was where the Times-Gazette parking lot is today.